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As evidence-of-theory that manipulation of Stage I metabolism would change the in vivo consequences with the SCBs, hypothermic results of 3 mg/kg JWH-018 or 5F-AB-PINACA have been identified utilizing radiotelemetry while in the presence or absence of the global CYP450 inhibitor 1-ABT in mice (Peppercorns are berries grown on trees in tropical area